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Production Chemist I

Bachem is a listed technology-based company focused on peptide chemistry. The company provides a full range of services to the pharma and biotech industries. It specializes in the development of innovative, efficient manufacturing processes and the reliable production of peptide-based active pharmaceutical ingredients. A comprehensive catalog of biochemicals and exclusive custom syntheses for research labs complete the service portfolio. Headquartered in Switzerland with subsidiaries in Europe, the US and Asia, the group has a global reach with more experience and know-how than any other company in the industry. Towards its customers, Bachem shows total commitment to quality, innovation and partnership.

In order to continue our organic growth, we are constantly looking for talent.

 

Your Responsibilities

This function is to develop peptide manufacture process, manufacture GMP material and perform related activities at Bachem.

 

Your Tasks

 

·         Perform synthesis process including solution phase and solid phase peptide synthesis, peptide resin cleavage, resin cleavage with HF or other chemical cocktails

·         Perform purification process by chromatography, crystallization and other techniques, and in-process test method

·         Follow approved GMP manufacture directions such as Master Batch Records, Standard Operation Procedures, Standard Test Procedures and other procedures to manufacture GMP materials,

          perform in-process test, package the product including other related activities

·         Perform project-planning and initiate raw material order-request. Receive raw materials, coordinate with QA/QC and Material Management for material release and monitor raw material inventories

·         Install, test equipment, operate and maintain equipment for manufacturing and in-process testing. The equipment includes analytical HPLC and prep HPLC system, lyophilizers, balances, reactors,

          HF cleavage equipment, diafiltration systems, water purification systems, oven, washing systems and others used in manufacture

·         Follow SOPs and approved directions to clean equipment, glassware used in GMP processes and maintain cleaning logs for each equipment

·         Follow and maintain GMP Documentation System. Investigate any process deviation and write process deviation report. Initiate document change request. Help quality control and assurance unit to

          maintain equipment calibration program

·         Dispose chemical waste generated in the manufacture

·         Routinely maintain/organize work areas (Hood, bench, floor, wall, etc.) and other designated areas at the manufacturing facility

·         Develop peptide-manufacturing processes including peptide/protein purification by chromatography, crystallization, and other techniques, and in process test methods

·         Develop processes for purification of chemicals other than peptides

·         Assist QA/QC for monitoring raw material inventories

·         Write Standard Operation Procedures, Standard Test Procedures, Master Batch Records and other related GMP documents

·         Follow approved GMP manufacture directions such as Master Batch Records, Standard Operation Procedures, Standard Test Procedures and other procedures to manufacture GMP material,

          perform in-process test, package the product and other related activities

·         Install, test equipment, operate and maintain equipment for manufacturing and in-process testing. The equipment includes analytical and prep HPLC systems, lyophilizers, balances, reactors,

          diafiltration systems, water purification systems, ovens, washing systems, and others used in manufacture

·         Follow SOPs and approved directions to clean equipment used in GMP processes, maintain cleaning log for each equipment, assist in equipment calibration program, and dispose chemical waste

          generated in the manufacture

·         Monitor compliance of Maintenance and Cleaning procedures of equipment and instruments used in GMP processes by periodically reviewing and signing off on maintenance and cleaning log for

          each equipment

·         Follow and maintain GMP Documentation System. Investigate any process deviation, write process deviation report, and initiate document change request

 

Your Profile

·         BS degree in Chemistry or related disciplines

·         1-3 years’ experience in the GMP industry

·         Use of analytical techniques/ instruments, such as, HPLC, GC, etc., and computer skills is highly desirable.

·         Ability to follow directions

·         Ability to effectively organize, multitasks, and works in a fast-paced, deadline driven work environment.

·         Excellent written and oral communications skills (technical writing a plus)

·         Ability to communicate in a proactive and solutions-focused manner, including keeping management aware of potential issues.

·         Exhibit professional interpersonal skills.

·         Communicate effectively and ability to work in a team environment.

·         Exhibit detail oriented documentation skills.

·         Ability to work independently and manage one's time

·         Basic computer knowledge, including Microsoft word and excel (used daily).

·         May work with hazardous materials and chemicals   

 

We Prefer

 

·         Experience with Peptides

·         General lab instrument ( MS UV Spectrometry) knowledge and operation experience

·         Knowledge of cGMP and FDA regulations a plus

 

We Offer

You will be part of a motivated team overseeing the entire development cycle of respective APIs. If you are looking for a new challenge and want to join a motivated team in an internationally renowned company, you should seize this opportunity.


Nearest Major Market: Los Angeles

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